
Get the ligand-target influence matrix
get_influence.RdGet the ligand-target influence matrix
Examples
# the ligands x genes regulatory potential matrix
ppi <- data.table::data.table(
from = c("L1", "SIG1", "L2", "SIG2"),
to = c("SIG1", "TF1", "SIG2", "TF2"),
weight = 1.0
)
grn <- data.table::data.table(
from = rep(c("TF1", "TF2"), each = 3),
to = c("G1", "G2", "G3", "G4", "G5", "G6"),
weight = 1.0
)
inf <- generate_ligand_target_influence(
ligand_seeds = list(L1 = "L1", L2 = "L2"),
ppi_network = ppi,
grn_network = grn,
params = params_ligand_target(ltf_cutoff = 0)
)
dim(get_influence(inf))
#> [1] 2 12