Generate the ligand to target influence matrices — rs_generate_ligand_target

Helper function to generate the ligand to target influence matrix for the NicheNet like approach.

Usage

rs_generate_ligand_target_influence(
  ligand_seeds,
  ppi_network,
  grn_network,
  n_nodes,
  params
)

ligand_seeds: List of integer vectors. The 0-indexed seed node(s) per ligand or ligand combination.
ppi_network: Named list. Contains the PPI network with the ligand to receptor to signalling to TFs. Must contain from and to (0-indexed node indices) and weight.
grn_network: Named list. Contains the gene regulatory network with the TF to target gene network. Must contain from and to (0-indexed node indices) and weight.
n_nodes: Integer. Number of total nodes.
params: Named list. The ligand-target diffusion parameters.

A dense matrix of ligands x n_nodes, rows in ligand_seeds order, with the ligand to target influence scores.