Run a single hypergeometric test. — rs_hypergeom

Given a set of target genes, this is a Rust implementation of an hypergeometric test testing for overenrichment of the target genes in the gene sets.

Usage

rs_hypergeom_test(
  target_genes,
  gene_sets,
  gene_universe,
  min_overlap,
  fdr_threshold
)

target_genes: String vector. Represents the target gene set.
gene_sets: List. Contains the strings that represent the gene sets to test against.
gene_universe: String vector. The features representing the gene universe from which the target genes and gene sets are sampled from.
min_overlap: Optional integer. Shall a filter be applied on the minimum of overlapping genes.
fdr_threshold: Optional float. Shall a filter be applied for the maximum tolerated FDR.

A list containing (only for the gene sets passing the filters):

pvals - The p-values from the hypergeometric test
odds_ratios - The calculated odds ratios
hits - The size of the overlap
gene_set_lengths - The length of the gene sets.
fdr - The FDR calculated across all gene sets (before filtering).
to_keep - 1-based indices of the gene sets that passed the (optional) thresholds.