Calculate the NicheNet ligand activity scores

Usage

rs_ligand_activity_scores(ligand_influence, in_gene_sets)

Arguments

ligand_influence

A ligand x background genes matrix that measures the ligand to target gene influence.

in_gene_sets

List of logical vectors, one per gene set, each of length ncol(ligand_influence). Genes of interest are TRUE, the background genes FALSE.

Value

A list with one element per gene set, each a list of per-ligand vectors (NaN where the metric is undefined):

• auroc - The Area Under the Receiver Operating Characteristic.

• aupr - The Area Under the Precision-Recall curve.

• aupr_corrected - The corrected AUPR.

• pearson - The Pearson correlations.

• spearman - The Spearman correlations.